Showing 3 results for Barzegari
R Golsha, V Kazeminejad, A Barzegari, S Besharat, F Ghasemi Kebria,
Volume 7, Issue 5 (supplement Issue( Bacteriology)[PERSIAN] 2014)
Abstract
Abstract
Background and Objective: The excessive use of broad-spectrum antibiotics will lead to drug resistance of microorganism and specially nosocomial organisms. Because of high incidence of antibiotic resistance in hospitals, we aimed to study antibiotic resistance to gram negative bacteria.
Material and Methods: This cross-sectional study was conducted on the data of biological samples (2006-2008), with positive culture result. Using antibiogram, microbial resistance to isolated microorganism was determined, and after culturing the samples, bacteria were identified by using differential media and antiserum. Then, antibiotic resistance was performed by disk diffusion.
Results: The most common gram-negative microorganism obtained from all cultures was Ecoli with the lowest drug resistance to Nitrofurantoin.
Conclusion: Based on the results, antimicrobial resistance pattern is not the same in different places and furthermore it is ever changing. Therefore, further research is needed to be done to have an accurate pattern of antibiotic resistance to provide effective treatment regimens.
Key words: Antibiotic Resistance Disk Diffusion Gram Negative Bacteria Gorgan
Amir Abbas Barzegari, Masood Hashemzaei, Ali Reza Aslihematti,
Volume 13, Issue 2 (Mar-Apr 2019)
Abstract
ABSTRACT
Background and Objectives: Current medications used for the treatment of burn wounds have some side effects and disadvantages. Oral or topical administration of probiotic bacteria is thought to be useful for treatment of skin disorders. The aim of this study was to evaluate effects of spray-dried Streptococcus thermophilus on healing of second-degree burn wounds.
Methods: After induction of second-degree burn on back of 80 male Wistar rats, the animals were randomly allocated to negative control (no treatment), first vehicle control (treatment with Eucerin), second vehicle control (treatment with skim milk) and experimental (treatment with bacterial ointment) groups. Wound healing rate (percent) and histopathological parameters of wound samples were evaluated on post-burn days 1, 3, 7 and 14.
Results: On days 3 and 7, macroscopic results showed that the healing rate was significantly higher in the experimental group compared to the control groups. Histopathological analysis of wound samples showed increased fibroblastic migration, collagen formation and re-epithelialization in the wounds treated with probiotic bacteria compared with the wounds of control groups.
Conclusion: Our results indicate that the topical use of spray-dried S. thermophilus could be useful for the treatment of burn wounds.
Keywords: Streptococcus thermophilus; Probiotics; Burns; Wound Healing; Rats.
Saba Bahrevar, Amir Abbas Barzegari, Shiva Khezri, Vahid Nejati,
Volume 15, Issue 5 (Sep-Oct 2021)
Abstract
Background and objectives: Safety is a key criterion for assessment of probiotics. The objective of this study was to evaluate safety of a new Iranian Lactobacillus paracasei IBRC-M 11110 strain as a candidate probiotic.
Methods: Eighteen male and 18 female Wistar rats were divided into two experimental and a control group. The experimental groups received the bacterium at two doses of 6 × 108 CFU/day and 6× 109 CFU/day for 28 days through oral gavage. The control groups received normal saline. On day 29, blood, serum and tissue samples were taken for analysis.
Results: Administration of the bacterium did not affect the general health and body weight of the rats during the study period. No significant change was observed in the blood parameters of rats in the experimental groups except for a significant decrease in mean corpuscular volume and mean corpuscular hemoglobin of male rats. Serum analysis showed a significant increase in the alanine transaminase and a significant decrease in aspartate transaminase in the experimental groups of male and female rats, respectively. In both male and female rats, a significant decrease in urea and a significant increase in creatinine were observed in the experimental groups. However, the above parameters were all within the normal range. Histopathological analysis of liver and kidney tissues also showed no abnormality.
Conclusion: The results confirm that L. paracasei IBRC-M 11110 was safe in the subacute toxicity test in Wistar rats.
