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Showing 3 results for Hojjati
Comparison of Hematologic and Biochemical Factors between Women with Gestational Diabetes and Healthy Pregnant Women
Alireza Ahmadi, Mahdi Ghasemian , Ali Asghar Ayatollahi, Murtadha Al-Khabori, Seyedeh Somayeh Hosseini Alarzi, Mohammad Taher Hojjati,
Volume 15, Issue 5 (Sep-Oct 2021)
Abstract 
Background and objectives: Diagnosis glucose intolerance in pregnancy is very important in preventing maternal and fetal complications. In this study, we compared hematological and biochemical characteristics of healthy pregnant women and women with gestational diabetes mellitus (GDM) to find predisposing and prognostic variables of GDM.
Methods: In this study, 80 pregnant women (at 24-28 weeks of pregnancy) were divided into a GDM group and non-GDM group by performing oral glucose tolerance test using 75 g glucose according to the International Association of the Diabetes and Pregnancy Study Groups criteria.
Results: The mean age of women with GDM was significantly higher than those without GDM (p=0.048). Other variables including body mass index, gestational age and daily sleep duration did not differ significantly between the two groups (P>0.05). There was a significant association between family history of diabetes and incidence of GDM (p=0.040). In addition, the C-peptide level was significantly higher in pregnant women with GDM (p=0.004).
Conclusion: Considering the role of C-peptide in predicting metabolic syndrome, it is suggested to use this factor for identification of GDM patients.
Relationships between serum lipid profile and HbA1c levels in patients with diabetes
Habibeh Sadat Mosavi , Mohammad Taher Hojjati , Khodaberdi Kalavi,
Volume 18, Issue 5 (Sep-Oct 2024)
Abstract
Background: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia, disturbed lipid metabolism, and cardiovascular disease (CVD). Poor glycemic control results in lipid and lipoprotein abnormalities, suggesting that dyslipidemia is secondary to insulin resistance or factors closely related to insulin resistance. Glaciated hemoglobin (HbA1c) is a routinely used marker for long-term glycemic control. This form of hemoglobin is chemically processed through post-translational glycosylation that reflects the plasma glucose concentration during the last two to three months.
Methods: This cross-sectional study was conducted on blood samples from 592 cases referred to Dezyani Specialty Clinic, affiliated with the Golestan University of Medical Sciences. In patients with diabetes mellitus (DM) and non-diabetic individuals, hemoglobin A1c (HbA1c), total cholesterol (T-chol), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured.
Results: In the study, there were 460 female participants (76.9%) and 132 male participants (23.1%). Among them, 403 (67.4%) were diabetic patients, and 193 (32.4%) were non-diabetic. HbA1c levels were significantly lower in younger individuals than in middle-aged participants (p=0.000). No significant difference was found between middle-aged and older individuals (p>0.121). LDL levels were significantly lower in the young group than in the middle-aged group (p<0.001). Total cholesterol (TC) was also significantly lower in the young group compared to middle-aged and older groups (p<0.001).
Conclusion: HbA1c can be a helpful lipid and glycemic control marker in diabetes.
 

JAK2 mutation, a potential cause of increasing Hemoglobin levels in symptomatic aged women
Zeinab Siahmargoie , Mohammad Taher Hojjati , Hadi Bazzazi , Khodaberdi Kalavi , Mana Zakeri , Hadi Joshaghani ,
Volume 19, Issue 2 (3-2025)
Abstract
Background: Polycythemia Vera (PV) is a myeloproliferative neoplasm (MPN) characterized by the overactivity of erythroid progenitors, leading to excessive red blood cell (RBC) production. More than 90% of PV cases harbor a Janus kinase 2 (JAK2) gene mutation. This study aimed to assess the prevalence of JAK2 mutations in individuals with elevated hemoglobin (Hb) levels referred to the laboratory by physicians.
Methods: In this descriptive cross-sectional study, genomic DNA from 72 patients was analyzed for JAK2 mutations using a TaqMan-specific probe.
Results: Of the 72 patients, 24 (33.3%) were women and 48 (66.6%) were men. JAK2 mutations were detected in 33 cases (45.5%), while 39 (54.2%) were negative. Notably, 15 of 24 female patients (62.5%) tested positive for the JAK2 mutation, compared to 18 of 48 male patients (37.5%).
Conclusion: Our findings suggest that screening for JAK2 mutations is particularly important in women with above-normal Hb levels.

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