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Showing 3 results for Hojjati
Comparison of Hematologic and Biochemical Factors between Women with Gestational Diabetes and Healthy Pregnant Women
Alireza Ahmadi, Mahdi Ghasemian , Ali Asghar Ayatollahi, Murtadha Al-Khabori, Seyedeh Somayeh Hosseini Alarzi, Mohammad Taher Hojjati,
Volume 15, Issue 5 (Sep-Oct 2021)
Abstract 
Background and objectives: Diagnosis glucose intolerance in pregnancy is very important in preventing maternal and fetal complications. In this study, we compared hematological and biochemical characteristics of healthy pregnant women and women with gestational diabetes mellitus (GDM) to find predisposing and prognostic variables of GDM.
Methods: In this study, 80 pregnant women (at 24-28 weeks of pregnancy) were divided into a GDM group and non-GDM group by performing oral glucose tolerance test using 75 g glucose according to the International Association of the Diabetes and Pregnancy Study Groups criteria.
Results: The mean age of women with GDM was significantly higher than those without GDM (p=0.048). Other variables including body mass index, gestational age and daily sleep duration did not differ significantly between the two groups (P>0.05). There was a significant association between family history of diabetes and incidence of GDM (p=0.040). In addition, the C-peptide level was significantly higher in pregnant women with GDM (p=0.004).
Conclusion: Considering the role of C-peptide in predicting metabolic syndrome, it is suggested to use this factor for identification of GDM patients.
Relationships between serum lipid profile and HbA1c levels in patients with diabetes
Habibeh Sadat Mosavi , Mohammad Taher Hojjati , Khodaberdi Kalavi,
Volume 18, Issue 5 (Sep-Oct 2024)
Abstract
Background: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia, disturbed lipid metabolism, and cardiovascular disease (CVD). Poor glycemic control results in lipid and lipoprotein abnormalities, suggesting that dyslipidemia is secondary to insulin resistance or factors closely related to insulin resistance. Glaciated hemoglobin (HbA1c) is a routinely used marker for long-term glycemic control. This form of hemoglobin is chemically processed through post-translational glycosylation that reflects the plasma glucose concentration during the last two to three months.
Methods: This cross-sectional study was conducted on blood samples from 592 cases referred to Dezyani Specialty Clinic, affiliated with the Golestan University of Medical Sciences. In patients with diabetes mellitus (DM) and non-diabetic individuals, hemoglobin A1c (HbA1c), total cholesterol (T-chol), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured.
Results: In the study, there were 460 female participants (76.9%) and 132 male participants (23.1%). Among them, 403 (67.4%) were diabetic patients, and 193 (32.4%) were non-diabetic. HbA1c levels were significantly lower in younger individuals than in middle-aged participants (p=0.000). No significant difference was found between middle-aged and older individuals (p>0.121). LDL levels were significantly lower in the young group than in the middle-aged group (p<0.001). Total cholesterol (TC) was also significantly lower in the young group compared to middle-aged and older groups (p<0.001).
Conclusion: HbA1c can be a helpful lipid and glycemic control marker in diabetes.
 

JAK2 mutation, a potential cause of increasing Hemoglobin level in symptomatic aged women
Zeinab Siahmargoie, Mohammad Taher Hojjati, Hadi Bazzazi, Khodaberdi Kalavi, Mana Zakeri, Hadi Joshaghani,
Volume 19, Issue 1 (4-2025)
Abstract
Background: Polycythemia Vera (PCV) is a type of myeloproliferative neoplasm (MPN) in which the progenitors of the erythroid lineage become overactive and produce large amounts of red blood cells (RBCs). More than 90% of people with PCV have a Janus kinase 2 (JAK2) gene mutation. In this study, we examined the status of possible JAK2 gene mutations in people with higher-than-normal hemoglobin (Hb) levels that physicians introduced to the laboratory.
Methods: In this descriptive cross-sectional study, JAK2 alleles were tested for possible JAK2 mutations in genomic DNA of 72 cases using a TaqMan-specific probe.
Results: Out of 72 patients, 24 were women (33.3%) and 48 (66.6%) were men, among them 39 (54.2%) were negative and 33 cases (45.5%) were positive for JAK2 mutation. The data also showed that 15 out of 24 female patients (62.5%) had positive JAK2 mutation, while in the male patients, 18 out of 48 (37.5%) were positive for JAK2 mutation.
Conclusion: According to our research, investigation of the Jak2 mutation, especially in women who had Hb levels upper than normal, seems to be necessary.
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