Nasrin Ramezani, Mahshid Dezhan, Saide Saadaat Khalili, Nader Shakeri, Kayvan Khoramipour,
Volume 17, Issue 5 (Sep-Oct 2023)
Abstract
Background: Omentin-1 plays an important role in insulin function. Despite numerous studies, the effect of interval training on this adipokine is still vague. This study aimed to elucidate the effect of high-intensity interval training (HIIT) on serum glucose, insulin, insulin resistance (IR), omentin-1 serum levels, and gene expression in the visceral adipose tissue in type 2 diabetic (T2D) rats.
Methods: In an experimental study, 20 male rats (8-10 weeks, weight: 250-270 g) were randomly divided into 2 groups: diabetic control (N=10) and diabetic training (N=10). The training protocol was 30 minutes of HIIT (1-min run, 2-min rest) performed 5 days a week for 4 weeks. Fasting blood glucose, insulin resistance, omentin-1 serum level, and gene expression were measured in the visceral fat 48 hours after the last exercise for both groups.
Results: The HIIT resulted in lower serum glucose and insulin resistance (P = 0.001), higher serum omentin-1 levels (P = 0.001), and higher visceral fat gene expression (P = 0.004) in the training group compared to the control group.
Conclusion: Lower serum glucose and insulin resistance and higher omentin-1 serum levels and gene expression in the training group can prove the effectiveness of HIIT training in T2D, although further research is required.
Saif Karim, Mahdi Zahedi, Nahid Poursharifi, Mehdi Khorami, Mohsen Tatar,
Volume 19, Issue 2 (3-2025)
Abstract
Objective: The purpose of this study was to investigate the impact of smoking on blood homocysteine, folic acid, and vitamin B12 levels in patients with cardiovascular diseases (CVD). Methods: We collected 90 participants with cardiovascular complications who were divided into two groups: Smokers (n=46) and non-smokers (n=44) groups. The serum levels of homocysteine, folic acid, and vitamin B12 were determined by the ELISA. Additionally, the systolic, diastolic blood pressure, and BMI were taken from patients. Results: Our results illustrated that the serum level of folic acid was significantly decreased in smoker patients (22.41±5.95) compared with the non-smokers group (28.05±4.13, p=0.000). In contrast, the serum level of homocysteine (p=0.958) and vitamin B12 (p=0.578) was not altered significantly between both groups. Our data also showed a negative correlation between folic acid and systolic blood pressure. No relationship was observed between folic acid and vitamin B12 and homocysteine in the smoking group. Conclusion: Our study showed that the levels of folic acid significantly decreased in CVD patients with smokers compared with non-smokers. A significant negative relationship was observed between folic acid and systolic blood pressure.
