Showing 3 results for SINGH
Bhumika Gupta, Shivani Kalhan, Shalini Shukla, Shalini Bahadur, Gyanendra Singh, Rambha Pathak,
Volume 15, Issue 6 (Special issue (Nov-Dec) 2021)
Abstract
Introduction: COVID 19 pandemic caused by SARS-COV2 virus has taken a toll all over the world. The susceptibility of various diseases like Helicobacter Pylori, Hepatitis B virus and Norwalk Virus and even SARS Corona Virus 1 have been associated with ABO blood groups. However, very limited data is available regarding the COVID 19 susceptibility and ABO blood groups. Methods: In the present report we investigated 500 admitted patients who were RTPCR positive for corona virus. Significant Tests were applied to study association of blood groups vis a vis disease severity, ICU admissions and assisted ventilation. Results: We found out that Type A blood group is more susceptible to severe COVID 19 infection, even though maximum patients were of type B blood group. We also found that type A blood group needed more ICU admission and assisted ventilation then non type A groups and difference was statistically significant. Conclusion: Patients with type A blood group COVID 19 patients with type A blood group might require more vigilant surveillance and aggressive treatment measures. Further studies are required to validate the disease susceptibility.
Qudsiya Ansari , Anisha Jain, Kailas Randad, Vinaya Singh, Akash Sarkate,
Volume 18, Issue 5 (Sep-Oct 2024)
Abstract
Osteoporosis-pseudoglioma syndrome (OPPG) is a rare disorder characterized by severe osteoporosis and vision impairment, due to mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene. This autosomal recessive disorder is characterized by fractures, bone fragility, and pseudoglioma with blindness in infancy. Herein, we present a rare case of OPPG syndrome in an infant who, at 80 days of life (DOL), exhibited multiple fractures without any ophthalmic findings at the time of presentation. This is relatively earlier presentation of the symptoms as fractures are more commonly seen after two years of life.
Anuradha Saini, Anjali Sharma, Mukul Singh, Shaily Goyal, Maninder Narang, Sunil Ranga,
Volume 19, Issue 2 (3-2025)
Abstract
Background & objectives: Sepsis is one of the most common cause of mortality among patients who are critically ill and in Intensive Care Units(ICU). Bacterial infection or sepsis leads to an increase in Neutrophilic CD64(nCD64) expression on activated polymorphonuclear leukocytes(PMNs). Early diagnosing of sepsis is very important in order to start timely and specific treatment. The availability of a rapid laboratory test with high specificity for sepsis in adult patients could aid in therapeutic decision making and reduce unnecessary antibiotic use.
Methods: Sepsis patients diagnosed as per sepsis-3 definition were included in this study. 2 ml blood sample was collected in EDTA & plain vial each for evaluation of nCD64, Procalcitonin(PCT) & high sensitivity C-reactive protein(hS-CRP). The samples were run on Flow cytometer, Nephelometer and Chemiluminescence for nCD64, hS-CRP and PCT respectively.
Result: The Positive Predictive Value(PPV) of nCD64 for prediction of sepsis was 92.68% and the Negative Predictive value(NPV) was 94.87%. Receiver operating curve(ROC) was plotted for indicating the diagnostic accuracy of nCD64(≥1.8), hS-CRP(≥3 mg/L) and PCT(≥0.4 ng/mL). Area under the curve(AUC) for nCD64 was highest[0.938(95%CI=0.876-0.999)] followed by hS-CRP[0.888(95%CI=0.807-0.968)] and PCT [0.850(95%CI =0.759-0.941)].
Conclusion: These findings are suggestive of the possibility that nCD64 determination was a useful tool for diagnosing infection in patients with septic syndrome, with a performance superior to that of hS-CRP and PCT.
