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Investigating the changes of hippocampal m-RNA gene expression of neurotrophin-3 and its receptor (Tropomyosin Receptor Kinase C) in the recovery of movements of rats with spinal cord injury during two types of endurance exercises
Sina Jalili Rasti, Sadegh Cheragh Birjandi, Mohammad Amin Younessi Heravi, Ali Yaghubi,
Volume 18, Issue 2 (Mar-Apr 2024)
Abstract
Background: This study aimed to investigate the effect of four weeks of selected endurance training on neurotrophin-3 (NT-3) and tropomyosin receptor kinase C (TrkC) gene expression in hippocampal areas of rats with spinal cord injury (SCI).
Methods: In this experimental study, the rats were separated into six equal groups. First, the animals were put under general anesthesia and had their SCI. Then, for four weeks, they were subjected to two kinds of endurance training programs. However, the control injury group received no intervention or training. Following the completion of the training regimes, molecular tests were done using the qRT-PCR technique to evaluate changes in the gene expression of NT-3 and TrkC from the animals' hippocampus.
Results: The expression of NT-3 and TrkC genes were significantly reduced in the SCI model compared to the healthy control group, but it was increased in the SCI + exercise 1 and SCI + exercise 2 groups compared to the SCI group. NT-3 levels did not vary significantly between the SCI + exercise 1 and SCI + exercise 2 groups, although alterations in TrkC levels altered.
Conclusion: In addition to enhancing locomotion in animals with SCI, the endurance training regimens in this research were effective on the expression of NT-3 and TrkC genes and may play a role in axonal development and neuronal survival in SCI recovery.

Evaluation prevalence of Rh system major antigens (D, C, c, E, e) and their phenotypes in blood donors of Golestan province, Iran
Seyed Sadegh Baniaghil, Fardin Balochi , Alireza Ahmadi,
Volume 18, Issue 3 (May-Jun 2024)
Abstract
Background: The understanding of blood group phenotypes is currently limited to the ABO and Rh blood group systems. This study aimed to determine the frequency of Rh system antigens (D, C, c, E, e) and the phenotypes of the system in blood donors. Identifying the blood group phenotypes of donors in any population is important for improving healthcare services and better serving patients.
Methods: This descriptive study was carried out on 575 donors (Turkmen and Fars) in blood transfusion centers in Golestan Province, Iran. A cell suspension (3-5%) from each sample was prepared in normal saline and exposed to Rh system antisera using the haemagglutination technique. The Rh phenotype was then determined based on the most common genotype.
Results: For the Rh system, the antigen frequencies of D, C, c, E, and e were 87.76%, 73.6%, 72.1%, 30.83%, and 93.59%, respectively. The most common phenotypes among the Turkmen and Fars donors were R1R1, R1r, and rr, respectively, while the least common phenotypes were R2Rz and ryry. The phenotypes r'r' and ryry were not detected in the Turkmen donors, and the phenotype r''r' was not identified in the Fars donors.
Conclusion: Identifying the prevalence of blood group antigens in donors from each region is crucial for organizing negative antigen blood units, preparing compatible blood for multitransfused patients, and preventing the development of alloantibodies in these patients.
 

Bronchopulmonary lophomoniasis in a Prisoner: A Case Report
Sadeghali Azimi, Bahareh Bashardoust, Mohammad Hadi Tajik Jalayeri,
Volume 19, Issue 2 (3-2025)
Abstract
Introduction: Bronchopulmonary lophomoniasis is an infrequent occurrence. In this study, we document a singular instance of pulmonary lophomoniasis exhibiting unconventional manifestations in Golestan province, Iran.
Case presentation: The case under examination pertains to a 47-year-old male inmate who has been encountering respiratory issues for a duration of four months, culminating in a diagnosis of lophomoniasis. Both blood and sputum cultures yielded negative results. Similarly, bronchoalveolar lavage tests for bacterial and fungal pathogens returned negative findings. However, bronchoalveolar lavage (BAL) results (microscopic) showed mild positive lophomoniasis targeting Lophomonas blattarum and Serum IgE=387 was relatively higher than normal limits.
Conclusion: The patient received treatment with metronidazole, leading to the resolution of all clinical complications within a span of four weeks.
 
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