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The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency
H Rafeemehr,
Volume 7, Issue 4 (1-2014)
Abstract
Abstract Background and Objective: Glutathione as a master antioxidant plays a key role in eliminating free radicals from your body and in preserving cell membrane integrity esp. blood cells. We aimed to assess the Erythrocyte Glutathione level of favism and non-favism neonates. Material and Methods: This study was conducted in Ekbatan hospitals of Hamadan (2009) on 15 favism patients and 60 non-favism ones matched by sex and age. Using Beutler method, the reduced Glutathione (GSH) level of red blood cells was measured. Results: Based on the results, the amount of erythrocyte GSH in favism patients was 14.99±4.62 mg/dl and that of controls was 58.2±10.59 mg/dl. Conclusion: the results show that the erythrocyte GSH in favism patients is significantly lower than that of non-favism subjects therefore, the former seems more likely to be afflicted by hemolytic crises owing to the use of oxidant stuff. Keywords: Favism Glutathone Neonates G6PD
Protective Effect of Ilex spinigera and Gleditsia caspica Extracts against Drug-Induced Hemolysis in Glucose-6-phosphate dehydrogenase-deficient Patients
Maryam Mohadjerani , Mansoore Damanjany ,
Volume 13, Issue 1 (1-2019)
Abstract
ABSTRACT
           Background and Objectives: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common X-linked disorder of human erythrocytes in which cells are susceptible towards hemolytic changes and could be destroyed by peroxides. Extracts of Ilex spinigera and Gleditsia caspica leaves have excellent free radical scavenging activity. We investigated the protective effects of these extracts against hemolysis induced by some drugs in G6PD-deficient erythrocytes.
           Methods: Blood samples were collected from males with and without G6PD deficiency. Hemolysis induced by aspirin, phenylhydrazine hydrochloride and phenacetin was assessed in the presence and absence of the extracts. The amount of released hemoglobin was determined by reading absorbance at 540 nm.
           Results: The methanol extract of G. caspica had significant protective effects against phenacetin-induced hemolysis in G6PD-deficient human erythrocytes (P<0.05). However, the I. spinigera extract had no significant anti-hemolytic effects on these cells.
           Conclusion: Our findings suggest that the extract of G. caspica could be a potential drug with antioxidant and anti-hemolytic properties for patients with G6PD deficiency.
           Keywords: Antihemolytic activity, Medicinal plant, G6PD deficiency, Gleditsia caspica, Ilex spinigera.

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