Showing 11 results for Lipid
A Marjani, A.r. Mansoorian, H. R. Joshaghani, K Heydari, A Sarikhani,,
Volume 1, Issue 1 (4-2007)
Abstract
Abstract Background and objective: Exposure of red blood cells to oxygen radicals can induce Lipid proxidation, hemoglobin damage and hemolysis of erythrocyte .The present study was designed to determine the alteration of plasma lipid peroxidation and erythrocyte Superoxide Dismutase and Glutathione Peroxidase enzyme activities in stored blood and to find out the quantitative alterations and the useful length of stored blood. Materials and Methods: First, the whole blood form 10 donors was taken. Then Red Blood Cells(RBC) were counted, the levels of Potassium(P) and lactate dehydrogenate activity(LDH) were measured to determine the amount of hemolysis, the plasma levels of malondialdehyde (MDA), erythrocyte Superoxide Dismutase(SOD) and Glutathione Peroxidase(GPx) were studied for determination of lipid peroxidation and antioxidant enzyme activities at the days of 0,1,3,5,7,9,11,13,15,17,19,21,23,25,27,29,31,33 and 35 of the storage. Results: upon storage time, the plasma levels of malondialdehyde (MDA) and Potassium and lactate dehydrogenate activity increased (P< 0.05) whereas erythrocyte Superoxide Dismutase and Glutathione Peroxidase enzyme activities and Red Blood Cells decreased (P< 0.05). The alterations of MDA, SOD, GPx, P, LDH and RBC in the measurement days were as follows: MDA, P and LDH significantly increased at the day of 9, 5 and 5 whereas SOD, GPx and RBC decreased at the day of 11, 7 and 29 respectively. Conclusion: The results of this study showed that the increased level of MDA and decreased SOD and GPx in stored blood can cause the beginning of hemolysis of erythrocyte therefore, it is necessary to control these factors before storing the donated blood. Keywords: lipid peroxidation, Superoxide Dismutase, Glutathione Peroxidase
Bazzazi, H., Govahi, M., Jahazi, A., Alizadeh, Sh., Naeimi Tabiee, E, Mokaram, R., Davarpanah, M R,
Volume 6, Issue 2 (10-2012)
Abstract
Abstract
Background and objectives: Recurrent miscarriage (RM) is one of the most common reproductive disorders, generally considered to be the loss of three or more pregnancies before viability. One of the causes of this disorder is the immunological factors such as autoantibodies associated with anti-phospholipid syndrome.
Material and Methods: this case-control study was conducted on 80 pregnant women divided into two equal groups of healthy and RM women in Gorgan. The subjects were asked to fill out a questionnaire and examined by a gynecologist to distinguish their condition, healthy or RM. The blood samples were kept at -20c and assessed by both ELISA 96 and automated ELISA processor with single dose ready-to-use test to measure β2GP1 autoantibodies of IgM and IgG.
Results: the results indicate that % 7.5 of RM patients are seropositive for Anti-β2GP1 IgG, and % 5 for Anti-β2GP1 IgM , but in healthy pregnants , % 7.5 are seropositive for Anti-β2GP IgG , and %7.5 for Anti-β2GP1 IgM. Family history of abortion in RM group (33.5%) is significantly higher than healthy one (17.5%).
Conclusion: based on the results, the difference between the level of Anti-β2GP1 IgM and Anti-β2GP IgG in case and control groups is not significant, but the production of this autoantibody is associated with pregnancy.
Key words: Autoantibody, Antiphospholipid syndrome, Recurrent Miscarriage
Dinarvand, Gh, Veis Raygani, A, Ghanbari, N,
Volume 9, Issue 1 (4-2015)
Abstract
Abstract
Background and Objective: T3 resin uptake test indicates the availability of thyroxin binding globulin (TBG), which is the carrier of a large amount of T3 and T4 in blood. We aimed to study the relationship between serum T3 Resin Uptake and serum lipids profile.
Material and Methods: The participants aged 14.80 ± 38.29 were both males (59 29.5%) and females (141 70.5 %). T3 Resin Uptake was measured by Immunoassay method and serum lipid profile components (cholesterol, triglycerides, HDL-C, LDL-C, and VLDL) were measured by the kit.
Results: Significant negative correlation was observed between serum T3 Resin Uptake and cholesterol, triglycerides and LDL-C (P≤ 0.05), but that was not the case for HDL-C and VLDL.
Conclusion: Serum T3 Resin Uptake can be evaluated to assess the risk factors related to cardiovascular disorders.
Keywords: Cholesterol, Triglycerides, T3 Resin Uptake, lipoprotein, Lipid Profile
Nasrin Zaer Ghodsi , Mohammad Reza Zolfaghari , Amir Fattah ,
Volume 10, Issue 1 (1-2016)
Abstract
Abstract
Background and Objective: High-intensity interval training (HIIT) is a recently proposed exercise protocol, which is time-effective. The aim of this study was to evaluate the effect of HIIT for 8 weeks on the lipid profile, C-reactive protein (CRP), fasting blood sugar (FBS) and anthropometric parameters of young women who do not exercise.
Methods: In this study, 20 young physically inactive women performed HIIT workouts for 8 weeks and 3 sessions per week. The training protocol consisted of 10-times treadmill running for 15 seconds at maximum effort and then 30 seconds of resting. Blood samples were taken while fasting, a day before and after the training and then the considered parameters were measured. Wilcoxon test was used to compare the obtained data.
Results: HIIT significantly reduced FBS, cholesterol, low-density lipoprotein, high-density lipoprotein /cholesterol ratio and CRP while increasing the HDL levels. There was a significant difference in the weight, body fat percentage, waist circumference, abdominal circumference and chest circumference of the subjects before and after the training (p <0.05).
Conclusion: HIIT can improve lipid, inflammatory and anthropometric parameters, thus it can be considered as a suitable alternative to time-consuming exercises, especially for physically inactive women who like to spend less time to achieve optimal physical wellness and body fitness.
Abbass Ghanbari-Niaki , Fatemeh Islami, Ramezanali Arabameri, Aliakbar Sharifiyan,
Volume 11, Issue 5 (9-2017)
Abstract
ABSTRACT
Background and Objectives: The aim of the present study was to investigate the effect of six weeks of volleyball training on lipid and lipoprotein profiles of elite high school male volleyball players in the Golestan Province (Iran) during preparation season for an international championship in France.
Methods: Training group included 12 elite volleyball players in students’ premier league and control group included 12 healthy non-athlete male students. The training group practiced at 60-85% of maximum heart rate for six weeks, 90 minutes per session, six sessions per week and three sessions a day (first session: technical practice, second session: tactical practice and third session: technical/tactical practice). Blood samples were taken after 12 hours of fasting both before and after the training.
Results: Level of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) and LDL-C/HDL-C increased in the training group (P> 0.05). However, there was a significant difference between the two groups in TC and LDL-C levels (P<0.05). Level of triglyceride, VLDL, and TC/HDL-C reduced in the training group after six weeks of training (P> 0.05).
Conclusion: Our results show that the six-week volleyball training during the preparation season can cause abnormalities in plasma lipid profile.
Keywords: Lipid, Lipoprotein, Volleyball Player
Amin Farzaneh Hesari , Akram Ebrahimi, Masoumeh Azizi Zanjani , Solmaz Mahdavi,
Volume 12, Issue 1 (1-2018)
Abstract
ABSTRACT
Background and Objectives: Elevated blood lipid levels are correlated with risk of cardiovascular disease, especially in overweight individuals. The beneficial effect of strength training on lipid profile has been well documented. However, the effect of strength training with flow blood restriction has not been established. The purpose of this study was to compare the effect of eight weeks of strength training with and without blood flow restriction on some of the cardiovascular risk factors in overweight females.
Methods: In this study, 28 overweight females aged 18 to 24 years were randomly assigned into three groups of blood flow restriction strength training (BFRT), traditional strength training (TRT) and control. Participants in the BFRT group performed eight weeks of strength training three sessions per week at 30% of 1-repetetion maximum, while participants in the TRT group performed the training at 65-80% of 1-repetetion maximum. Cardiovascular variables, systolic blood pressure and diastolic blood pressure were measured before and after the exercise training. Data was analyzed using descriptive statistics, paired t-test and one-way analysis of variance.
Results: Triglyceride level decreased significantly in the BFRT (p=0.022) and TRT (p=0.038) groups compared with the control group. Moreover, there were no significant differences in the body mass, waist-to-hip ratio, body mass index, high-density lipoprotein, low-density lipoprotein, and cholesterol levels between the study groups (P≥0.05).
Conclusion: Our findings suggest that the BFRT and TRT may not be suitable for preventing or even reversing the physiological changes induced by obesity.
Keywords: Resistance Training, Lipids, lipoprotein, overweight.
Mahtab Moazzami , Asra Askari ,
Volume 12, Issue 2 (3-2018)
Abstract
ABSTRACT
Background and objectives: The aim of this study was to investigate the effects of six months of aerobic exercise on lipid profile, inflammatory markers, and risk factors of cardiovascular disease in middle-aged obese women.
Methods: Fifteen obese woman (age range: 35 to 45 years) with BMI of ≥30 Kg/m2 were enrolled via purposeful and convenience sampling. The participants were randomly divided into training (n=10) and control (n=5) groups. Blood samples (7 ml) were taken from all participants before the first training session and after the last training session. The women performed 60 minutes of aerobic exercise at 55-65% of heart rate reserve, three sessions a week, for six months. Data was analyzed using independent and paired t-tests and Mann-Whitney U and Wilcoxon tests at significance of 0.05.
Results: After the six-month aerobic exercise, C-reactive protein, low-density lipoprotein, triglycerides, total cholesterol and high-density lipoprotein/total cholesterol decreased significantly. The exercise intervention also caused a significant increase in the concentrations of high-density lipoprotein and apolipoprotein A.
Conclusion: Aerobic exercise can reduce the level of inflammatory markers associated with risk of cardiovascular disease and atherosclerosis.
Keywords: Lipid profile, Inflammatory markers, Obese women, Apolipoprotein, Aerobic exercise.
Mojtaba Abbasi, Amirhooman Asadi, Hadis Musavi,
Volume 13, Issue 6 (11-2019)
Abstract
Background and Objectives: Reduced insulin secretion in Type II Diabetes Mellitus (T2DM) results in fat accumulation in hepatocytes and increase in liver enzymes. The hepatocyte destruction due to non-alcoholic fatty liver is associated with increased risk of cardiovascular diseases. Therefore, the aim of this study is to evaluate the association of liver transaminases with lipid profile in T2DM patients compared to healthy subjects.
Methods: A total of 1000 subjects (500 males and females with T2DM and 500 healthy subjects) participated in this case-control study. Diagnosis of T2DM was made based on the World Health Organization (WHO) criteria. Fasting blood samples (5 ml) were obtained from all subjects in the morning and the serum was extracted for the assessment of biochemical parameters was used to compare parameters between healthy and T2DM patients. Data were analyzed by SPSS version 20 and using Mann-Whitney test and Spearman correlation coefficient.
Results: The serum total cholesterol (TCH), triglyceride, Alanine Aminotransferase (ALT), Aspartate Transaminase (AST), TCH/high density lipoprotein (HDL-C) ratio and atherogenecity index plasma were significantly higher in T2DM group compared to healthy individuals (p≤0.006). Among the lipid profile parameters only Risk ratio (TCH/HDL-C) was positively correlated with ALT (p=0.037) while no significant correlation was observed for other variables (P>0.05)
Conclusion: T2DM Patients have higher lipid profile, atherogenecity index and liver enzymes compared to healthy individuals. Furthermore, TCH/HDL-C was significantly correlated with ALT.
Maryam Lotfi, Mohammad Azizi, Worya Tahmasebi, Parviz Bashiri,
Volume 14, Issue 2 (3-2020)
Abstract
ABSTRACT
Background and Objective: It is desirable for athletes, especially female soccer players, to consume beetroot beverage during training as a way of improving both health and performance ,. Therefore, the objective of this study was to assess the effect of beetroot juice intake on lipid profile in female soccer players.
Methods: Young and well-trained female soccer players (N=20) were included in a randomized placebo-controlled crossover study. They were categorized into two groups: experimental (beetroot beverage, n=10, age: 23.20±0.91 years, BMI: 22.57±1.54(kg/m2)) and control (placebo, n=10, age: 23±0.81 years, BMI: 23.13±0.58(kg/m2)). Subjects drank either 200 ml concentrated beetroot beverage or an equal amount of placebo 2 hours prior to their trainings for six weeks (18 session). Blood samples were taken 24 hours before and after trials. All data were compared in pretest and posttest via paired sample t-test and independent sample t-test. All statistical analyses were performed at (P≤0.05) by SPSS (version22).
Results: Beetroot juice intake increased plasma high density lipoprotein (t= -60.88, P<0.05). Triglyceride, total cholesterol, and low density lipoprotein were reduced (P<0.05). Compared with placebo, beetroot juice reduced the concentrations of triglyceride, total cholesterol, and low density lipoprotein (P<0.05).
Conclusion: Regular beetroot juice intake has significant effects on lipid profile in female soccer players, hence its suggestion for preventing diseases such as hypercholesterolemia and hypertension in female soccer players.
Key words: Soccer, Training, Dietary Supplements, Lipids.
Abdolrasoul Hakim Elahi, Rasoul Sharifi, Minoo Mahmoodi, Seyed Mehrdad Kassaee,
Volume 14, Issue 5 (9-2020)
Abstract
Background and objectives: The aim of this study was to evaluate the effectiveness of octopine (phytogenic-derivative of arginine) on antioxidant indices, trace elements and lipid profiles of a mouse model of breast cancer.
Methods: In this study, 48 Balb/c mice were divided into six groups: healthy control, cancer control, cancer group receiving 50 mg of octopine, cancer group receiving 100 mg of octopine and cancer group receiving 150 mg of octopine. The octopine treatment was carried out for three weeks. The 4T1 cell line was used to induce cancer. Fasting blood samples were taken from mice to evaluate lipid profile, copper and zinc levels. Malondialdehyde, superoxide dismutase and glutathione peroxidase activity in breast tumor tissues was evaluated. Data were analyzed by SPSS 18 software using one-way ANOVA and t-test.
Results: Octopine had no significant effect on superoxide dismutase and glutathione peroxidase activity in the treatment group compared with the control cancer group. However, it significantly increased total antioxidant capacity and decreased malondialdehyde activities. Furthermore, treatment with octopine significantly decreased serum zinc, copper, TG, cholesterol and low-density lipoprotein levels but significantly increased high-density lipoprotein compared with the untreated cancer group.
Conclusion: Octopine administration is effective in reducing some oxidative stress indices and improving trace elements abnormalities and lipid profile in mouse models of breast cancer.
Habibeh Sadat Mosavi , Mohammad Taher Hojjati , Khodaberdi Kalavi,
Volume 18, Issue 5 (9-2024)
Abstract
Background: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia, disturbed lipid metabolism, and cardiovascular disease (CVD). Poor glycemic control results in lipid and lipoprotein abnormalities, suggesting that dyslipidemia is secondary to insulin resistance or factors closely related to insulin resistance. Glaciated hemoglobin (HbA1c) is a routinely used marker for long-term glycemic control. This form of hemoglobin is chemically processed through post-translational glycosylation that reflects the plasma glucose concentration during the last two to three months.
Methods: This cross-sectional study was conducted on blood samples from 592 cases referred to Dezyani Specialty Clinic, affiliated with the Golestan University of Medical Sciences. In patients with diabetes mellitus (DM) and non-diabetic individuals, hemoglobin A1c (HbA1c), total cholesterol (T-chol), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured.
Results: In the study, there were 460 female participants (76.9%) and 132 male participants (23.1%). Among them, 403 (67.4%) were diabetic patients, and 193 (32.4%) were non-diabetic. HbA1c levels were significantly lower in younger individuals than in middle-aged participants (p=0.000). No significant difference was found between middle-aged and older individuals (p>0.121). LDL levels were significantly lower in the young group than in the middle-aged group (p<0.001). Total cholesterol (TC) was also significantly lower in the young group compared to middle-aged and older groups (p<0.001).
Conclusion: HbA1c can be a helpful lipid and glycemic control marker in diabetes.
