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Abstract Background and Objective: Trichomonas vaginalis is a pathogenic agent known worldwide and affects about 180 million annually. We aimed to investigate the prevalence of Trichomonas vaginalis in diabetic patients referred to diabetic research center. Material and Methods: In this descriptive-analytic study, 215 women referring to the Diabetic Center in Kermanshah Province were investigated for Trichomonas vaginalis. After collecting the data by a questionnaire, the samples were obtained from posterior fornix by sterile swabs and sent for assessing by direct microscopy and Dorset medium. Results: Totally, 1.3 percent of the women were confirmed to be infected with T. vaginalis. Conclusion: The range of blood sugar cannot remarkably affect the prevalence of T. vaginalis. Given the limitations of this study and low prevalence compared to similar studies, we recommend further comprehensive research for better understanding. Keywords: Trichomonas Vaginalis, Diabet, Prevalence

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Background and objectives: Trichomonas vaginalis causes human trichomoniasis, a common type of protozoan vaginitis. Due to the increasing incidence of drug-resistant trichomoniasis, new pharmacological research is needed. The aim was investigation of the activity of Ferula pseudalliacea against T. vaginalis, and preliminary phytochemical analysis of its extracts.
Methods: Essential oil and various extracts of F. pseudalliacea roots, including n-hexane, ethyl acetate and methanol, were obtained. Susceptibility testing of the plant products was done on five T. vaginalis isolates by using microtiter plate method. Minimum lethal concentration (MLC) and growth inhibitory percent (GI%) of sub-MLC concentration were reported, after 24 and 48 hours’ exposures. Phytochemical screening of the extracts was done using standard procedure.
Results: Antitrichomonal effect of the plant products depended on time and concentration. The greatest effect was observed in 48-hour exposure. The essential oils and n-hexane extract of F. pseudalliacea demonstrated a remarkable activity with MLC of 250 µg/ml and following by the ethyl acetate (MLC=500 µg/ml) and methanol extract (MLC=1000 µg/ml), with GI% 92.8, 50.6, 85.2, and 42.8, respectively. The bioactive constituents of the extracts were coumarins, terpenoids, steroids, phenols, tannins and glycosides.
Conclusion: The results of this study demonstrated in vitro antitrichomonal properties of F. pseudalliacea. Therefore, further studies are needed to investigate the potential of the antitrichomonal activity of its bioactive constituents.