Saif Karim, Mahdi Zahedi, Nahid Poursharifi, Mehdi Khorami, Mohsen Tatar,
Volume 19, Issue 2 (3-2025)
Abstract
Objective: The purpose of this study was to investigate the impact of smoking on blood homocysteine, folic acid, and vitamin B12 levels in patients with cardiovascular diseases (CVD). Methods: We collected 90 participants with cardiovascular complications who were divided into two groups: Smokers (n=46) and non-smokers (n=44) groups. The serum levels of homocysteine, folic acid, and vitamin B12 were determined by the ELISA. Additionally, the systolic, diastolic blood pressure, and BMI were taken from patients. Results: Our results illustrated that the serum level of folic acid was significantly decreased in smoker patients (22.41±5.95) compared with the non-smokers group (28.05±4.13, p=0.000). In contrast, the serum level of homocysteine (p=0.958) and vitamin B12 (p=0.578) was not altered significantly between both groups. Our data also showed a negative correlation between folic acid and systolic blood pressure. No relationship was observed between folic acid and vitamin B12 and homocysteine in the smoking group. Conclusion: Our study showed that the levels of folic acid significantly decreased in CVD patients with smokers compared with non-smokers. A significant negative relationship was observed between folic acid and systolic blood pressure.
