Sun, Jun 29, 2025
1- Assistant Professor of Infectious Disease, Infectious Diseases Research Center, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
2- Department of Medical Parasitology and Mycology, Faculty of Paramedicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Assistant Professor of Pulmonary Diseases, Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran ,drtgtg@yahoo.com
2- Department of Medical Parasitology and Mycology, Faculty of Paramedicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Assistant Professor of Pulmonary Diseases, Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran ,
Abstract: (233 Views)
Introduction: Bronchopulmonary lophomoniasis is an infrequent occurrence. In this study, we document a singular instance of pulmonary lophomoniasis exhibiting unconventional manifestations in Golestan province, Iran.
Case presentation: The case under examination pertains to a 47-year-old male inmate who has been encountering respiratory issues for a duration of four months, culminating in a diagnosis of lophomoniasis. Both blood and sputum cultures yielded negative results. Similarly, bronchoalveolar lavage tests for bacterial and fungal pathogens returned negative findings. However, bronchoalveolar lavage (BAL) results (microscopic) showed mild positive lophomoniasis targeting Lophomonas blattarum and Serum IgE=387 was relatively higher than normal limits.
Conclusion: The patient received treatment with metronidazole, leading to the resolution of all clinical complications within a span of four weeks.
Case presentation: The case under examination pertains to a 47-year-old male inmate who has been encountering respiratory issues for a duration of four months, culminating in a diagnosis of lophomoniasis. Both blood and sputum cultures yielded negative results. Similarly, bronchoalveolar lavage tests for bacterial and fungal pathogens returned negative findings. However, bronchoalveolar lavage (BAL) results (microscopic) showed mild positive lophomoniasis targeting Lophomonas blattarum and Serum IgE=387 was relatively higher than normal limits.
Conclusion: The patient received treatment with metronidazole, leading to the resolution of all clinical complications within a span of four weeks.
References
1. Alba-Romero JJ, Nogueda-Torres B, Sánchez-Manzano RM, Alba-Romero DL, Martínez-Romero A. Differential diagnosis of lophomaniasis in patients with COVID-19 in northern Mexico: a case report. Iberoamerican Journal of Medicine. 2023;6(1):23-27. [View at Publisher] [DOI] [Google Scholar]
2. Mokhtarian K, Taghipour S, Nakhaei M, Taheri A, Sharifpour A, Fakhar M, et al. Molecular evidence of emerged pulmonary lophomoniasis due to Lophomonas blattarum among hospitalized patients in southwestern Iran: A national registry-based study. Interdiscip Perspect Infect Dis. 2022:2022:6292823. [View at Publisher] [DOI] [PMID] [Google Scholar]
3. Fakhar M, Nakhaei M, Sharifpour A, Kalani H, Banimostafavi ES, Abedi S, et al. First molecular diagnosis of lophomoniasis: the end of a controversial story. Acta Parasitol. 2019;64(2):390-3. [View at Publisher] [DOI] [PMID] [Google Scholar]
4. Nakhaei M, Fakhar M, Sharifpour A, Ziaei Hezarjaribi H, Banimostafavi ES, Nazar E. Global status of emerging Lophomonas infection: a systematic review of reported cases (1993-2020). Interdiscip Perspect Infect Dis. 2022:2022:3155845. [View at Publisher] [DOI] [PMID] [Google Scholar]
5. Ghatee MA, Nakhaei M, Sharifpour A, Fakhar M, Mohamadi N, Soleymani M, et al. Geospatial Analysis and Molecular Epidemiologic Study of Emerging Pulmonary Lophomoniasis in Iran: A National Registry-Based Study. J Parasitol Res. 2023;2023:1039186. [View at Publisher] [DOI] [PMID] [Google Scholar]
6. Camargo-Assis F, Máttar S, González M. Lophomonas blattarum cockroach parasite that causes uncommon pneumonia in humans. Rev MVZ Cordoba. 2020;25(1):1948. [View at Publisher] [DOI] [Google Scholar]
7. Ding Q, Shen K. Pulmonary Infection with Lophomonas blattarum. Indian J Pediatr. 2021;88(1):23-27. [View at Publisher] [DOI] [PMID] [Google Scholar]
8. Mirzazadeh F, Berenji F, Amini M, Salehi M, Shamsian A, Abdolmajid Fata, et al. Lophomonas blattarum in asthmatic patients and control group. J Res Med Dent Sci. 2017;5(5):1-5. [View at Publisher] [DOI] [Google Scholar]
9. Martinez-Girón R, Woerden HC. Lophomonas blattarum and bronchopulmonary disease. J Med Microbiol. 2013;62(11):1641-48. [View at Publisher] [DOI] [PMID] [Google Scholar]
10. Neves Coelho F, Borralho J, Baptista-Fernandes T, Toscano C, Carmo ME. Characterization of Lophomonas spp. Infection in a Population of Critical Care Patients. Infect Dis Rep. 2024;16(1):83-92. [View at Publisher] [DOI] [PMID] [Google Scholar]
11. Chaudhury A, Parija SC. Lophomonas blattarum: A new flagellate causing respiratory tract infections. Trop Parasitol. 2020;10(1):7-11. [View at Publisher] [DOI] [PMID] [Google Scholar]
12. Ding Q, Shen K. Pulmonary infection with Lophomonas blattarum. Indian J Pediatr. 2021;88(1):23-7. [View at Publisher] [DOI] [PMID] [Google Scholar]
13. Chen S, Meng Z. Bronchopulmonary Lophomonas blattarum infection: A case report. Chin J Parasitol Parasit Dis. 1993;11:28. [Google Scholar]
14. Jorjani O, Bahlkeh A, Koohsar F, Talebi B, Bagheri A. Chronic Respiratory Allergy Caused by Lophomonas blattarum: A Case Report. Medical Laboratory Journal. 2018;12(2). [View at Publisher] [DOI] [Google Scholar]
15. Talebian M, Berenji F, Amini M, Sayedi SJ, Shamsian A, Afzalaghaee M, et al. A study about clinical symptoms and laboratory signs of adult and pediatric patients with Lophomonas blattarum. Journal of Research in Medical and Dental Science. 2018;6(1):312-7. [View at Publisher] [DOI] [Google Scholar]
16. Zeng H, Kong X, Chen X, Luo H, Chen P, Chen Y. Lophomonas blattarum infection presented as acute exacerbation of chronic obstructive pulmonary disease. J Thorac Dis. 2014;6(6):E73-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
17. Taheri A, Fakhar M, Sharifpour A, Nakhaei M, Banimostafavi ES. Lophomonas and Mycobacterium co-infection: the first molecular evidence to overcome potential diagnostic pitfalls. Oxf Med Case Reports. 2022;2022(7):omac064. [View at Publisher] [DOI] [PMID] [Google Scholar]
18. Jalayeri MH, Zakariaei Z, Fakhar M, Sharifpour A, Banimostafavi ES, Soleymani M. Ruptured pulmonary hydatid cyst and lophomoniasis comorbidity in a young man: a rare case. Oxf Med Case Reports . 2023;2023(3):omad023. [View at Publisher] [DOI] [PMID] [Google Scholar]
19. Tajik Jalayeri MH, Sharifi far RA, Lashkarbolouk N, Mazandarani M. The co-infection of pulmonary hydatid cyst, lophomoniasis and tuberculosis in a patient with resistant respiratory symptoms; a case report study. BMC Infect Dis. 2024;24(1):11. [View at Publisher] [DOI] [PMID] [Google Scholar]
20. Jalayeri MH, Lashkarbolouk N, Mazandarani M. Diagnosis of pulmonary lophomoniasis in an elderly anthracosis patient with resistant respiratory symptoms: A literature review and a case report study. Clin Case Rep. 2024;12(6):e9085. [View at Publisher] [DOI] [PMID] []
21. Vélez NP, Vintimilla RO, Orellana SA. Lung infection caused by Lophomonas blattarum. Arch Bronconeumol. 2021;57(9):594-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Enamad
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.